Date Posted: 10/26/2026
Hiring Organization: Rose International
Position Number: 509845
Industry: Biotech/Healthcare
Job Title: Scientist - Viral Vector Development
Job Location: South San Francisco, CA, USA, 94080
Work Model: Onsite
Shift: First Shift
Employment Type: Temporary
FT/PT: Full-Time
Estimated Duration (In months): 7
Min Hourly Rate($): 45.00
Max Hourly Rate($): 50.00
Must Have Skills/Attributes: Cell Culture, Data Analysis, PCR, Presentations, Production Support
Experience Desired:
Proficient in mammalian cell culture and general molecular biology techniques. (3+ yrs),
Require strong data analysis and presentation skills (3+ yrs),
Previous experience with ex vivo CAR T engineering using lentivirus is a must (3+ yrs)
Required Minimum Education: Master’s Degree
Preferred Education: Ph.D / Doctorate
**C2C is not available**
Job Description
Required Education:
• MS/PhD degree in Cell Biology, Molecular Biology, Virology, Biochemistry, Bioengineering, Genetics, or a related discipline with 3+ years of laboratory research or industrial experience.
Required Skills:
• Proficient in mammalian cell culture and general molecular biology techniques such as transient plasmid transfection, PCR, qPCR, ddPCR, dPCR and Western blot.
• Require strong data analysis and presentation skills.
• Previous experience with ex vivo CAR T engineering using lentivirus is a must.
• Must be self-motivated, detail-oriented, analytical, highly organized, and have excellent communication and interpersonal skills.
Preferred Skills:
• Working experience with lentivirus or AAV production in adherent or suspension cells, process development, statistical DOE modeling and automated liquid handling are highly desirable.
• Experience with flow cytometer operations, electronic notebook and BSL2 facility management are also strong plus.
Summary:
We are seeking a collaborative and driven Scientist to accelerate our lentiviral vector (LVV) and adeno-associated virus (AAV) generation platforms. The primary objective of this engagement is to increase viral vector production throughput and yield to support rapid turnaround for screening and pipeline studies. This is an exciting opportunity to work with a cutting-edge research team, contribute to the development of innovative viral vector based therapeutic modalities and support our research community in applying viral vectors as powerful research tools.
Responsibilities:
• Integration of automation and high-throughput LVV and AAV workflows. Implement and program automated liquid handling systems (e.g., Integra Assist Plus, Bravo etc) for high-throughput transfection, transduction, sample dilution and cell seeding. Incorporate high-throughput shaker arrays or automated micro-scale bioreactor platforms (e.g., Ambr® 15 or Ambr® 250) to run parallel mini-scale expression runs. Troubleshoot liquid-class parameters, pipetting precision, and plasticware compatibility to minimize batch-to-batch variation.
• Develop and optimize suspension-based lentiviral vector (LVV) upstream production platform. Design, execute, and characterize robust, scalable upstream processes, from seed train expansion through shake flask production and primary harvest. Apply Design of Experiments (DOE) methodologies to systematically explore multivariate interactions including multi-plasmid transient transfection conditions, plasmid ratios, transfection reagents (e.g., PEI, lipid nanoparticles), DNA-to-cell ratios, harvest timing, feed schedule and chemical enhancers to boost packaging efficiency.
• Development and establishment of downstream LVV process. Evaluate and identify optimal low-shear depth filtration and microfiltration protocols tailored to large scale virus production. Develop and optimize ultrafiltration/diafiltration (TFF) and chromatographic purification methodologies.
• Conduct cutting-edge analytics for LVV and AAV QC. Perform physical and functional characterization of viral vectors to interpret quality attributes and ensure high-quality services. Integrate QC in the uptream/downstream process development for rapid identification of factors for improvement.
• Data, Inventory and Protocol Management: Analyze multivariate process datasets using excel, Prism or AI agent to facilitate fast progression of projects. Maintain a meticulously organized virus inventory and registry utilizing digital informatics platforms to ensure data integrity and traceability. Author standardoperating procedures (SOPs), technical reports and tech transfer protocols. Present data in group and department meetings. - **Only those lawfully authorized to work in the designated country associated with the position will be considered.**
- **Please note that all Position start dates and duration are estimates and may be reduced or lengthened based upon a client’s business needs and requirements.**
Benefits:
For information and details on employment benefits offered with this position, please visit here. Should you have any questions/concerns, please contact our HR Department via our secure website.
California Pay Equity:
For information and details on pay equity laws in California, please visit the State of California Department of Industrial Relations' website here.
Rose International is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender (expression or identity), national origin, arrest and conviction records, disability, veteran status or any other characteristic protected by law. Positions located in San Francisco and Los Angeles, California will be administered in accordance with their respective Fair Chance Ordinances.
If you need assistance in completing this application, or during any phase of the application, interview, hiring, or employment process, whether due to a disability or otherwise, please contact our HR Department.
Rose International has an official agreement (ID #132522), effective June 30, 2008, with the U.S. Department of Homeland Security, U.S. Citizenship and Immigration Services, Employment Verification Program (E-Verify). (Posting required by OCGA 13/10-91.).
It is a great pleasure being a part of the Rose International Team.
Toni, Consultant
You are customer service oriented. No matter whether it was the Recruiter or someone in Human Resources/Payroll, you were responsive. That to me is key!
Tonya, Consultant
Any time I did have a question and called, the phone was always answered, and my question/concern was immediately resolved.
Sally, Consultant
It was great working for Rose International. Everyone was extremely helpful.
Rosann, Consultant
I had a very positive experience working for Rose. The entire process is very efficient and easy.
Joanne, Consultant
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