NEW JOB OPENING
OLIGONUCLEOTIDE SCIENTIST
IN South San Francisco, CA, USA!

Education:



• BS/MS in Organic Chemistry or related discipline



Required Skills:



• The candidate must have hands-on experience in oligonucleotide synthesis using automated oligo synthesizers, novel nucleic acid chemistry, oligonucleotide purification and characterization using HPLC and mass spectrometry.

• The pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics is preferred.

• A good understanding of nucleic acid therapeutic modalities, modification chemistries,sequence selection, and mechanism of action is preferred.

• Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or bio-conjugation is desirable.



Preferred Skills:



• Good communication and interpersonal skills are essential and will be evaluated during the interview process.

• The ideal candidate should be highly motivated and have strong problem-solving, analytical, communication and organizational skills.



Summary:



• We are seeking a creative, self-motivated, collaborative Contractor/Scientist-II to join the Nucleic Acid Design and Discovery (NADD) team within ProteinSciences (PS) department at Client.

• We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group.

• Experience in delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred.

• The successful candidate will join an interdisciplinary chemistry team working in RNAi biology research and will contribute positively to its developing culture.



Responsibilities:



• The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology

and oncology, to help build a comprehensive therapeutic discovery strategy.

• Good understanding and also troubleshooting experience in oligonucleotide synthesis, impurity profiling is a plus.

• Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC and desalting units.

• Perform literature reviews, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression.

• Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.

• Maintaining a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.

• **Only those lawfully authorized to work in the designated country associated with the position will be considered.**

• **Please note that all Position start dates and duration are estimates and may be reduced or lengthened based upon a client’s business needs and requirements.**