Date Posted: 10/13/2026
Hiring Organization: Rose International
Position Number: 509085
Industry: Biotech/Healthcare
Job Title: Scientist
Job Location: San Diego, CA, USA, 92134
Work Model: Onsite
Employment Type: Temporary
FT/PT: Full-Time
Estimated Duration (In months): 8
Min Hourly Rate($): 40.00
Max Hourly Rate($): 49.00
Must Have Skills/Attributes: Cell Culture, Flow Cytometry
Experience Desired:
Expertise in flow cytometry acquisition and analysis (2+ yrs),
Experience with non-viral transfection methods (2+ yrs)
Required Minimum Education: Bachelor’s Degree
Preferred Education: Master’s Degree
**C2C is not available**
Job Description
Required Education:
• Bachelor’s in Immunology, Molecular Biology, Bioengineering, or a related biological science
Preferred Education:
• Master’s degree in Immunology, Molecular Biology, Bioengineering, or a related biological science
Required Skills:
• We require at least 2 years of hands-on wet lab experience, preferably within an industry setting.
• Mastery of aseptic technique and experience in isolating primary T cells from PBMCs is essential.
• Expertise in flow cytometry acquisition and analysis is a non-negotiable requirement for this role.
• Preference will be given to candidates who have direct experience with non-viral transfection methods and those who are comfortable using liquid-handling robotics to scale screening efforts.
Preferred Skills:
• Strong communication skills are vital, as you will be expected to present clear, data-driven updates during weekly campaign sprint meetings.
Summary:
We are seeking a highly motivated and detail-oriented Contract Wet Lab Scientist to join our Discovery Biology team. This role is central to a high-priority binder screening campaign, where you will be responsible for executing the bench-level assays required to identify and validate novel therapeutic candidates for T-cell-based therapies. The successful candidate will serve as a core operator within our screening funnel, focusing on the transition from binder discovery to functional validation. This is a contingent position (typically 6–12 months) designed for a scientist who thrives at the bench and excels in the fast-paced environment of a drug discovery campaign. The primary objective is to characterize the potency, specificity, and safety of candidate binders—such as scFvs or VHHs—within the context of engineered T-cell responses.
Responsibilities:
• A significant portion of this role involves the non-viral engineering of T cells.
• You will be responsible for delivering genetic material (such as mRNA or transposon-based DNA systems) into primary human T cells using advanced electroporation or nucleofection platforms.
• Following transfection, you will monitor cell viability and recovery, ensuring high-efficiency expression of synthetic receptors before proceeding to functional testing.
• Beyond engineering, you will execute high-throughput screening assays to assess binder affinity and functionality.
• This includes maintaining and expanding primary human T cells and Jurkat cell lines using impeccable aseptic techniques.
• You will perform multi-color flow cytometry (FACS) to evaluate surface expression levels and phenotypic markers, using software like FlowJo to analyze and interpret the resulting data.
• Functional characterization is a critical component of this campaign.
• You will be expected to run a variety of assays to measure T-cell activation, including cytotoxicity assays (using IncuCyte live-cell imaging or LDH release) and cytokine profiling via ELISA, MSD, or Luminex.
• You will also track T-cell proliferation using dyes like CFSE. All experimental procedures, including precise protocol deviations and raw data, must be recorded meticulously in an Electronic Lab Notebook (ELN) to ensure data integrity for regulatory filings. - **Only those lawfully authorized to work in the designated country associated with the position will be considered.**
- **Please note that all Position start dates and duration are estimates and may be reduced or lengthened based upon a client’s business needs and requirements.**
Benefits:
For information and details on employment benefits offered with this position, please visit here. Should you have any questions/concerns, please contact our HR Department via our secure website.
California Pay Equity:
For information and details on pay equity laws in California, please visit the State of California Department of Industrial Relations' website here.
Rose International is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender (expression or identity), national origin, arrest and conviction records, disability, veteran status or any other characteristic protected by law. Positions located in San Francisco and Los Angeles, California will be administered in accordance with their respective Fair Chance Ordinances.
If you need assistance in completing this application, or during any phase of the application, interview, hiring, or employment process, whether due to a disability or otherwise, please contact our HR Department.
Rose International has an official agreement (ID #132522), effective June 30, 2008, with the U.S. Department of Homeland Security, U.S. Citizenship and Immigration Services, Employment Verification Program (E-Verify). (Posting required by OCGA 13/10-91.).
I have been very pleased with my experience with Rose International. Everyone that I encountered was very helpful and courteous.
Stephanie, Consultant
It is a great pleasure being a part of the Rose International Team.
Toni, Consultant
Thanks for the opportunity. If in the future I ever need a job, I would like to work for Rose International.
David, Consultant
Rose International was not only attentive and responsive, but they were very professional and helpful whenever I called or needed any assistance.
Diane, Consultant
Working for Rose International was the most pleasant assignment I have ever had. They were always on top of situations when necessary, and very helpful. I was very proud to be an employee of Rose International, and would recommend anyone to try to work with them.
Melvon, Consultant
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